| CatalogCode: | | NLS3840 |
| ProductName: | | Gastric Inhibitory Polypeptide Receptor Antibody |
| Product Description: | | Rabbit Polyclonal anti-Gastric Inhibitory Polypeptide Receptor |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide [KLH conjugated] made to the N-term extracellular |
| CrossReactivity: | | Human. The immunogen used for this antibody has 100/78% homology/identity with the rat protein. |
| Packaging: | | 0.05 ml of affinity purified sera in Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide. |
| Uses: | | Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. |
| Background: | | GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries. |
| Storage: | | Store at 4C short term. Aliquot and store at -70C long term. Avoid freeze thaw cycles. |
| Host_Name: | | Rabbit |
| ListPrice: | | 325 |
| AppSummary: | | IHC-Fr, IHC-P |
| SpeciesSummary: | | Hu |
| ProteinTarget: | | Gastric Inhibitory Polypeptide Receptor |
| PackageSize: | | 0.05 ml |
| NotesMain: | | Genbank accession number: NM_000164 |
| more information: | | company product webpage |