| CatalogCode: | | NLS3488 |
| ProductName: | | Frizzled-2 Antibody |
| Product Description: | | Rabbit Polyclonal anti-Frizzled-2 |
| Clonality: | | Polyclonal |
| Immunogen: | | 3rd extracellular domain of human |
| CrossReactivity: | | Human |
| Packaging: | | 0.05 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | | Immunohistochemistry of Formalin fixed paraffin embedded sections. |
| Localization: | | Integral membrane protein |
| Background: | | FZD2 is a Frizzled Receptor that mediates Wnt signaling, which is required for proper axis development in the embryo. FZD2 is developmentally regulated. Studies of rat FZD2 indicate that the protein signals through a calcium-releasing pathway and that FDZ2 expression modulates protein kinase C (PKC) localization and stimulates PKC activity in vitro. Increased levels of FZD2 mRNA have been observed in primary gastric cancer and in head and neck squamous carcinoma and gastric cancer cell lines. FZD2 expression has been documented in human brain, heart, kidney, lung, colon, ovary and stomach. High levels of expression have been observed in fetal kidney and lung and adult colon and ovary. ESTs have been isolated from human tissue libraries, including cancerous kidney, lung, lymph and testis, and normal blood, cervix, embryo and kidney. |
| Storage: | | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Host_Name: | | Rabbit |
| Buffer: | | Phosphate buffered saline, pH 7.7, |
| ListPrice: | | 375 |
| AppSummary: | | IHC-P |
| SpeciesSummary: | | Hu |
| ALTnames: | | Anti-Frizzled homolog 2 antibody; Anti-Frizzled2 antibody; Anti-Fz 2 antibody; Anti-Fz2 antibody; Anti-FZD 2 antibody; Anti-FZD2 antibody; Anti-FzE 2 antibody; Anti-FzE2 antibody; Anti-hFz 2 antibody; Anti-hFz2 antibody |
| ProteinTarget: | | Frizzled-2 (FZD2) |
| PackageSize: | | 0.05 ml |
| more information: | | company product webpage |