| CatalogCode: | NLS2668 |
| ProductName: | Smoothened Drosophila Homolog Antibody |
| Product Description: | Rabbit Polyclonal anti-Smoothened Drosophila Homolog |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide [KLH conjugated] made to the N-terminal extracellular domain of human. |
| CrossReactivity: | Human and mouse. Other species have not been tested. |
| Packaging: | 0.05 ml Affinity purified Rabbit antisera. |
| Uses: | This antibody is useful for immunohistochemistry with formalin fixed paraffin embedded tissues and Western blot. |
| Localization: | Membrane |
| Background: | Smoothened, a Frizzled Receptor, is homologous to the Drosophila segment polarity Smo gene. It associates with the Patched protein to mediate the cellular response to the Hedgehog secreted protein signal, which controls patterning and growth during vertebrate development. Smoothened is activated in a number of human tumors and can function as an oncogene in basal-cell carcinomas. Smoothened expression has been documented in bladder, blood, brain, the central nervous system, skin, and ureter. ESTs have been isolated from amnion, bone, brain, breast, embryo, eye, heart, nerve, and skin libraries. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Host_Name: | Rabbit |
| Buffer: | PBS [pH7.7] |
| ListPrice: | 375 |
| AppSummary: | IHC, WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-Gx antibody, anti-SMO antibody, anti-Smoothened homolog (Drosophila) antibody, anti-Smoothened homolog precursor (SMO) (Gx protein) antibody, anti-Smoothened antibody, anti-SMOH antibody |
| ProteinTarget: | Smoothened Drosophila Homolog |
| PackageSize: | 0.05 ml |
| Homology: | 93% identity and homology with rat protein. |
| NotesMain: | Genbank accession number: NM_005631 |
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