| CatalogCode: | NB600-904 |
| ProductName: | c-Fos Antibody |
| Product Description: | Rabbit Polyclonal anti-c-Fos |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) (N terminal). |
| Specificity: | Reacts with c-Fos |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Packaging: | 1 ml IgG purified Rabbit antisera. |
| Localization: | Nuclear |
| Control: | A-431 and HeLa lysate |
| Background: | The Fos gene family consists of 4 members: Fos, FosB, FosL1, and FosL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP1. As such, the Fos proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the Fos gene has also been associated with apoptotic cell death. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS |
| ListPrice: | 325 |
| AppSummary: | IP, WB, IHC-P |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | Anti-AP1 antibody, anti-V-Jun antibody, anti-Cellular oncogene fos antibody, anti- FBJ murine osteosarcoma viral v fos oncogene homolog antibody, anti- FBJO steosarcoma Virus antibody, anti- FOS antibody, anti- FOS protein antibody, anti- G0 G1 switch regulatory protein 7 antibody, anti- G0S7 antibody, anti- Oncogene FOS antibody, anti- Proto oncogene protein c fos antibody, anti- v fos FBJ murine osteosarcoma viral oncogene homolog antibody |
| ProteinTarget: | Fos (c-Fos) |
| PackageSize: | 1 ml |
| GeneralRef: | General / background references:Shaulian E & Karin M AP-1 in cell proliferation and survival. Oncogene 20:2390-400 (2001). Liebermann DA et al. AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis. Int J Oncol 12:685-700 (1998). Karin M et al. AP-1 function and regulation. Curr Opin Cell Biol 9:240-6 (1997). Curran T Fos and Jun: oncogenic transcription factors. Tohoku J Exp Med 168:169-74 (1992). Bos TJ et al. The carboxy terminus of the viral Jun oncoprotein is required for complex formation with the cellular Fos protein. Oncogene 4:123-6 (1989). Rauscher FJ et al. Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev 2:1687-99 (1988). |
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