| CatalogCode: | NB600-811 |
| ProductName: | Tafazzin Antibody |
| Product Description: | Goat Polyclonal anti-Tafazzin |
| Clonality: | Polyclonal |
| Immunogen: | Synethtic peptide: C-HLKTQAEQLHNH, representing the C Terminus of the human protein according to NP_000107.1; NP_851828.1; NP_851829.1; NP_851830.1 |
| CrossReactivity: | Human. Other species have not been tested. Expected cross-reactivity based upon sequence homology: Human, Mouse, Rat, Dog |
| Packaging: | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | Peptide ELISA: antibody detection limit dilution 1:32,000.
Western Blot: Approx 28.5 kDa band observed in Human Heart lysates (calculated MW of 33.5kDa according to NP_000107.1, 30.295kDa according to NP_85182958.1, 31.7kDa according to NP_85182959.1 and 2958.5 according to NP_851830.1). Recommended concentration: 0.3-1.0 ug/ml. |
| Background: | The tafazzin protein plays a key role in Barth syndrome. Barth syndrome appears to be a disease of the mitochondria. Tafazzin protrudes into the intermembrane space from both the outer and inner membranes. The tafazzin protein may be associated with cardiolipin, the signature lipid of mitochondria, which has been implicated in other diseases, including those of the heart. Tafazzin may be important in repairing lipids, including cardiolipin, but it is not determined. Tafazzin's association with both the outer membrane and the inner membrane is consistent with its ability to modify a membrane component such as cardiolipin. This antibody is expected to recognise isoforms 1to 4 (NP_000107.1; NP_851828.1; NP_851829.1; NP_851830.1, respectively). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Goat |
| Buffer: | Tris-saline containing 0.02% Na azide (pH7.3) with 0.5% BSA |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-TAZ antibody, anti-tafazzin (cardiomyopathy antibody, anti-dilated 3A (X-linked) endocardial fibroelastosis 2 Barth syndrome)antibody, anti-HGNC:11577 antibody, anti-BTHS antibody, anti-CMD3A antibody, anti-EFE antibody, anti-EFE2 antibody, anti-G4.5 antibody, anti-XAP-2antibody, anti-OTTHUMP00000061673 antibody, anti-cardiomyopathy antibody, anti-dilated 3A (X-linked) antibody, anti-tafazzin antibody |
| ProteinTarget: | Tafazzin |
| PackageSize: | 0.1 mg |
| GeneralRef: | Brandner K, Mick DU, Frazier AE, Taylor RD, Meisinger C, Rehling P. Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes: implications for Barth Syndrome. Mol Biol Cell. 2005 Nov;16(11):5202-14 PMID: 16135531 |
| Gene_Id: | 6901 |
| Omim_ID: | NB100-73081 |
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