| CatalogCode: | NB600-719 |
| ProductName: | Granzyme A Antibody |
| Product Description: | Mouse Monoclonal anti-Granzyme A (GA6) |
| Clone: | GA6 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant Granzyme A (Human). |
| CrossReactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.05 mg Mouse ascites. |
| Uses: | IHC-P: Use at a dilution of 1/50 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.WB: Use at an assay dependent dilution. Predicted molecular weight: 31.4 kDa(recognises a 60kD disulphide-linked homodimeric protein).Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted, Cytoplasmic granules. |
| Background: | The biological function of Granzyme A is unclear. It would appear that the molecule may have a role in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection. |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Preservative: 0.09% Sodium AzideConstituents: PBS |
| ListPrice: | 285 |
| AppSummary: | IHC-P, WB |
| SpeciesSummary: | Hu |
| ProteinTarget: | Granzyme A |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Kummer JA et al. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins. J Immunol Methods 163:77-83 (1993). |