| Catalog Code: | NB600-646 |
| Product Type: | Primary Antibody |
| Product Name: | Huntingtin Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 3064 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-Huntingtin |
| Cross Reactivity: | Predicted to react with Human and Pig due to sequence homology. Not yet tested in other species. |
| Species Summary: | Hu, Po |
| Background: | Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, |
| Alternate Names: | anti-HD antibody, anti-HD protein antibody, anti-HDH antibody, anti-HTT antibody, anti-HUNTINGTON CHOREA antibody, anti-Huntington's disease protein homolog antibody, anti-IT15 antibody, anti-ZHD antibody |
| Immunogen: | Synthetic peptide: RSRSGpSIVE, corresponding to amino acids 416-424 of Human Huntingtin |
| Specificity: | Detects a 190kDa band in PC-3 cells, which may correspond to Huntingtin. Stains neuronal cytoplasm in immunohistochemistry (the expected localisation). The antibody has not been conclusively tested for specificity for phospho S421 Huntingtin. |
| Purity: | Immunogen affinity purified |
| Buffer: | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
| Packaging: | 0.1 mg of IgG purified antisera |
| Package Size: | 0.1 mg |
| Concentration: | 0.8 mg/ml |
| Uses: | This product can be used for ELISA against 0.1ug of the immunizing peptide. * Not yet tested in other applications. *Optimal dilutions should be determined by the end user. |
| Application Summary: | ELISA |
| Notes Main: | **Investigative antibodies are immunogen affinity purified and are shown by ELISA to have high titre values against their immunogen. We are currently testing them for use in Western blotting. At this stage, there can be delays. We sometimes experience pro |