| Catalog Code: | NB600-622 |
| Product Type: | Primary Antibody |
| Product Name: | ATM Antibody |
| List Price: | 295 |
| Clonality: | Monoclonal |
| Gene ID: | 472 |
| Host: | Mouse |
| Clone: | 7C10D8 |
| Product Description: | Mouse Monoclonal anti-ATM (7C10D8) [Ser1981] |
| Phosphorylated: | Ser1981 |
| Cross Reactivity: | Cross-reacts with Human and mouse. |
| Species Summary: | Hu, Mu |
| Background: | ATM, the gene mutated in the hereditary disease ataxia-telangiectasia, codes for a protein kinase that acts as a master regulator of cellular responses to DNA double-strand breaks. ATM is normally inactive and the question of how it is activated in the ev |
| Alternate Names: | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia tel |
| Immunogen: | Corresponds to amino acids 1974-1988. |
| Specificity: | This monoclonal anti-ATM antibody recognizes the phosphorylated epitope in native and overexpressed proteins found in various tissues and extracts. |
| Purity: | Ascites |
| Buffer: | 0.02 M Potassium Phoshate, 0.15 M Sodium Chloride, pH 7.2 |
| Packaging: | 0.05 mg Ascites Mouse ascites. |
| Package Size: | 0.05 mg |
| Concentration: | 1.0 mg/ml |
| Uses: | This antibody clone has been optimized for IHC, but may also be used for western blotting, immunoprecipitation or immunofluorescence microscopy. Indirect immunoperoxidase staining on formaldehyde-fixed, de-paraffinized tissue sections and/or formalin-fixe |
| Application Summary: | ELISA, IHC, IF, WB |
| Product References: | 1. Bakkenist, C. J. & Kastan, M. B. (2003). DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506. 2. Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. (2004) Phosphorylation of SMC1 is a criti |
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