| Catalog Code: | NB600-582 |
| Product Type: | Primary Antibody |
| Product Name: | SREBP1 Antibody |
| List Price: | 295 |
| Clonality: | Monoclonal |
| Gene ID: | 6720 |
| Host: | Mouse |
| Clone: | 2A4 |
| Isotype: | IgG1 kappa |
| Product Description: | Mouse Monoclonal anti-SREBP1 (2A4) |
| Cross Reactivity: | Cross-reacts with Human and Hamster. Not yet tested in other species. |
| Species Summary: | Ha, Hu |
| Background: | SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to cond |
| Alternate Names: | anti-Sterol regulatory element binding protein 1 antibody, anti-SRBP1 antibody, anti-Sterol regulatory element-binding transcription factor antibody |
| Immunogen: | Recombinant protein encoding N terminal amino acids 301-407. |
| Epitope: | aa 301-407. |
| Localization: | Cytoplasmic and nuclear |
| Buffer: | 10mM PBS [pH7.4] with 0.2%BSA |
| Packaging: | 0.5 ml Mouse ascites. |
| Package Size: | 0.5 ml |
| Uses: | For Western Blotting, 2hrs at RT is recommended. This antibody detects a band of 125 kDa (precursor) and 60-70 kDa(cleaved), which corresponds to the predicted molecular weight of SREBP 1.Optimal dilutions should be determined by the end user. |
| Application Summary: | WB |
| Storage: | Store at 4C. Do not freeze. |
| General References: | Wang X et al. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 15:1012-20 (1996). Wang X et al. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves |