| Catalog Code: | NB600-569 |
| Product Type: | Primary Antibody |
| Product Name: | ATM Antibody |
| List Price: | 295 |
| Clonality: | Monoclonal |
| Gene ID: | 472 |
| Host: | Mouse |
| Clone: | ATX08 |
| Isotype: | IgG1 |
| Product Description: | Mouse Monoclonal anti-ATM (ATX08) |
| Cross Reactivity: | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Species Summary: | Hu, Mu |
| Background: | ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage cause |
| Alternate Names: | anti-AT complementation group A antibody, anti-AT complementation group C antibody, anti-AT complementation group D antibody, anti-AT complementation group E antibody, anti-AT mutated protein antibody, anti-AT1 antibody, anti-ATA antibody, anti-Ataxia tel |
| Immunogen: | Recombinant full length human ATM protein. |
| Localization: | Nuclear |
| Specificity: | This antibody reacts with a 350 kD protein known as ATM (Ataxia Telangiectasia Mutated). |
| Purity: | IgG purified |
| Packaging: | 500 microlitres |
| Package Size: | 0.5 ml |
| Uses: | IHC: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. Suggested incubation period is 30 minutes at room temperature. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buff |
| Application Summary: | IHC |
| Storage: | Store at 4C. Do not freeze. |
| General References: | Crawford T.O. Ataxia telangiectasia. <i>Semin Pediatr Neurol</i> <b>5</b>:287-94 (1998).Knittweis J. An ataxia telangiectasia model: inefficient cell differentiation and possible reversal by serine protease inhibitors, tumor necros |
| Novus References: | Miyasaka, Y., et al. The Role of the DNA Damage Checkpoint Pathway in Intraductal Papillary Mucinous Neoplasms of the Pancreas. Clin. Cancer Res. 2007 13: 4371-4377. |