| CatalogCode: | NB600-560 |
| ProductName: | GFAP Antibody |
| Product Description: | Rabbit Polyclonal anti-GFAP |
| Clonality: | Polyclonal |
| Immunogen: | Glial fibrillary acidic protein isolated from cow spinal cord. |
| Specificity: | In the central nervous system, this antibody stains astrocytes and some groups of ependymal cells.
However, in the peripheral nervous system, it stains Schwann cells, satellite cells and enteric glial cells. |
| CrossReactivity: | This antibody reacts with human, cat, chicken, cow, guinea pig, hamster, kangaroo, monkey, mouse, rat and sheep. |
| Packaging: | 6 ml protein A purified Rabbit antisera. |
| Uses: | This antibody has been pretitered and quality controlled to work on formalin-fixed paraffin-embedded as well as acetone fixed cryostat tissue sections.
No further titration is required.
We suggest an incubation period of 30 minutes at room temperature.
However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. |
| Localization: | Astrocyte Marker |
| Control: | Brain |
| Background: | Glial fibrillary acidic protein (GFAP) is a member of the class III intermediate filament protein family. It is heavily, and specifically, expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non myelinating Schwann cells in peripheral nerves. In addition, neural stem cells frequently strongly express GFAP. Antibodies to GFAP are therefore very useful as markers of astrocytic cells. In addition many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | n/a |
| Host_Name: | Rabbit |
| Buffer: | PBS with sodium azide |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IHC-P |
| SpeciesSummary: | Bv, Ch, Ha, Hu, Mu, Mk, Rt, Gp, Fe, Sh |
| ALTnames: | anti-Astrocyte antibody, anti-Glial Fibrillary Acidic Protein antibody, anti-FLJ45472 antibody |
| ProteinTarget: | GFAP |
| PackageSize: | 6 ml |
| GeneralRef: | General References:
i) Viale et al. Arch A Pathol Anat 418:339 (1991) |
| NotesMain: | GFAP is Glial Fibrillary Acidic Protein |
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