| CatalogCode: | NB600-555 |
| ProductName: | L1CAM Antibody |
| Product Description: | Mouse Monoclonal anti-L1CAM (UJ127) |
| Clone: | UJ127 |
| Clonality: | Monoclonal |
| Immunogen: | Homogenous suspension of 16 week human fetal brain. |
| Specificity: | NB 600-555 is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin. It does not bind to pediatric or adult brain. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.5 ml protein G purified Mouse ascites. |
| Uses: | By Western blot, this antibody detects a band of 220-240 kDa, which corresponds to the predicted molecular weight of L1CAM. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Optimal dilutions should be determined by the end user. |
| Localization: | Cell membrane. |
| Control: | IMR-5 cells. |
| Background: | The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, adductus thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, neural migration and in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | 10mM PBS [pH7.4] with 0.2%BSA |
| ListPrice: | 295 |
| AppSummary: | IHC, IF, IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-antigen identified by monoclonal R1 antibody; anti-CD171 antibody; anti-HGNC:7086 antibody; anti-HSAS1 antibody; anti-L1 cell adhesion molecule antibody; anti-MASA antibody; anti-MIC5 antibody; anti-N CAML1 antibody; anti-NEURAL CELL ADHESION MOLECULE L1 PRECURSOR antibody; anti-S10 antibody, anti-SPG1 antibody |
| ProteinTarget: | L1CAM |
| PackageSize: | 0.5 ml |
| GeneralRef: | 1. Kemshead J, et. al. Inter J Cancer, 1983; 31:187-195. 2. Patel, et. al. Biochem Soc Trans, 1990; 18:274. |