| CatalogCode: | NB600-552 |
| ProductName: | CD26 / DPP IV Antibody |
| Product Description: | Mouse Monoclonal anti-CD26 / DPP IV (202-36) |
| Clone: | 202-36 |
| Clonality: | Monoclonal |
| Immunogen: | Human T cell clone. |
| CrossReactivity: | Cross-reacts with Human and Rat. Does not cross-react with Pig or Sheep. Not yet tested in other species. |
| Packaging: | 0.5 ml IgG purified acites. |
| Uses: | This antibody can be used in Immunofluorescence and Flow Cytometry. Not tested in other applications.Optimal dilutions should be determined by the end user. |
| Localization: | Cell membrane. |
| Control: | HEP-G2 cells. Lymph node or tonsil. |
| Background: | CD26 [also known as dipeptidyl peptidase IV (DPP IV), adenosine deaminase (ADA)-binding protein]. is an atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocyte cells and is upregulated during T-cell activation. CD26 is also expressed on activated B cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Cross-linking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Protein A purified |
| Isotype: | IgG2b kappa |
| Host_Name: | Mouse |
| Buffer: | 10mM PBS [pH7.4] containing 0.09% sodium azide with 0.2% BSA |
| ListPrice: | 285 |
| AppSummary: | FACS, IF |
| SpeciesSummary: | Hu, Rt, Po (-), Sh (-) |
| ALTnames: | anti-ADABP antibody, anti-ADCP2 antibody, anti-Adenosine deaminase complexing protein 2 antibody, anti-Dipeptidyl peptidase iv antibody, anti-Dipeptidylpeptidase 4 antibody, anti-DPP4 antibody, anti-DPPIV antibody, anti-Intestinal dipeptidyl peptidase antibody, anti-T cell activation antigen CD26 antibody, anti-TP103 antibody |
| ProteinTarget: | CD26 / DPP IV |
| PackageSize: | 0.5 ml |
| GeneralRef: | 1. Kishimoto T. et al., eds. Leukocyte Typing VI, p478-489 and p1128, Garland Publishing, Inc, New York and London, 1997. 2. Fleischer B. Immunol Today 1994, 15:180-184. 3. Abbott CA. et. al. Immunogenetics 1994, 40:331-338. 4. Valenzuela A et. al. Adv Exp Med Biol 1997, 421:185-192. 5. Cheng HC, et al. J Biol Chem. 1998 273(37):24207-24015. 6. Morimoto C and Schlossman SF. The structure and function of CD26 in the T-cell immune response. Immunol Rev 1998, 161:55. 7. Fleischer B. CD26: a surface protease involved in T-cell activation. Immunol Today 1994 15:180. 8. Tanaka T, et al. Cloning and functional expression of the T cell activation antigen CD26. J Immunol 1992, 149:481. 9. Hegen M, et al. Function of dipeptidyl peptidase IV (CD26, Tp103) in transfected human T cells. Cell Immunol 1993, 146:249. 10. Bohm SK, et al. Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter. Biochem J 1995, 311:835. 11. Kameoka J, et al. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science 1993 261:466. 12. Bauvois B A. Collagen-binding glycoprotein on the surface of mouse fibroblasts is identified as dipeptidyl peptidase IV. Biochem J 1988, 252:723. 13. Torimoto Y, et al. Coassociation of CD26 (dipeptidyl peptidase IV) with CD45 on the surface of human T lymphocytes. J Immunol 1991 147:2514. 14. Oravecz T, et al. CD26 expression correlates with entry, replication and cytopathicity of monocytotropic HIV-1 strains in a T-cell line. Nat Med 1995, 1:919. 15. Dong RP, et al. Characterization of adenosine deaminase binding to human CD26 on T cells and its biologic role in immune response. J Immunol 1996 156:1349. |
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