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| Catalog Code: | NB600-488 |
| Product Name: | ZIC1 Antibody |
| Product Description: | Rabbit Polyclonal anti-ZIC1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 1.0 mg/ml |
| Immunogen: | Synthetic peptide - which corresponding to amino acids 25-42 of mouse Zic-1. This domain is completely conserved in human ZIC-1. |
| Specificity: | Detects a band of approximately 60 kDa. |
| Cross Reactivity: | Cross-reacts with Human and Mouse. Not yet tested in other species. |
| Packaging: | 0.05 mg IgG purified Rabbit antisera. |
| Uses: | Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Nuclear |
| Background: | The Zic-1 gene, which encodes a zinc finger protein, is expressed in the developing or matured central nervous system in a highly restricted manner. The Zic gene is expressed in granule cells that make synaptic contact with Purkinje cells. Clearly Zic-1 is a gene critical to cerebellar pattern formation. The expression of Zic genes is first detected at gastrulation and at neurulation, becomes restricted to the dorsal neural ectoderm and the dorsal paraxial mesoderm. Zic-2 and Zic-3 are highly similar genes, especially in their product's zinc finger motif and by comparison of their genomic organization in that they share common exon-intron boundaries and belong to the same gene family. By comparison in function, Zic-2 is essential for the formation of the brain and Zic-3 is important for right and left axis formation. The Zic-1 gene has been mapped to chromosome 9 in mouse. The 5' flanking region of the Zic-1 gene contains a region-specific enhancer determined to be essential in in vivo and in vitro deletion analysis. The temporal profile of mRNA expression differs for each of the Zic gene products. The Drosophila odd-paired gene is highly homologous to the Zic gene family. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7 |
| Application Summary: | immunohistochemistry 1/100, immunofluorescence 1/100, Western Blot 1/1250 |
| Species Summary: | Hu, Mu, |
| Alternate Names: | Anti-Odd paired homolog Drosophila antibody; Anti-Zic 1 antibody; Anti-ZIC antibody; Anti-Zic family member 1 (odd-paired Drosophila homolog) antibody; Anti-Zic family member 1 antibody; Anti-Zinc finger protein of the cerebellum 1 antibody; Anti-Zinc finger protein ZIC 1 antibody; Anti-Zinc finger protein ZIC1 antibody; Anti-ZNF 201 antibody; Anti-ZNF201 antibody |
| Package Size: | 0.05 mg |
| Preservative: | Sodium Azide |
| General References: | Aruga, J., et al. (1996). The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired. J. Biol. Chem. 12;271(2): 1043-7. Mikoshiba, K., (1999). Mamalian neural induction and brain pattern formation. Keio J. Med. Sep48(3): 111-23. Nagai, T. et al., (1997). The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev. Biol. Feb15;182(2): 299-313. Aruga, J. et al., (2000). A 5' segment of the mouse zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord. Brain Res. Mol. Brain Res.31;78(1-2): 15-25. |
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