| Catalog Code: | NB600-483 |
| Product Type: | Primary Antibody |
| Product Name: | NFkB1 Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 4790 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-NFkB1 |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Species Summary: | Hu |
| Background: | NFkB is a transcription regulator that is activated by various intra and extra cellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of |
| Alternate Names: | anti-DNA binding factor KBF1 antibody, anti-DNA binding factor KBF1 EBP1 antibody, anti-EBP 1 antibody, anti-EBP1 antibody, anti-MGC54151 antibody, anti-NF kappa B antibody, anti-NFKB p105 antibody, anti-NFKB p50 antibody, anti-Nuclear factor kappa B DNA |
| Immunogen: | Synthetic peptide: AEDDPYLGRFEQMF conjugated to KLH. |
| Localization: | Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I kappa B). |
| Specificity: | Recognition is at the N-terminus. This antibody will supershift NFkB complexes containing the human p50 subunit.Control peptide (NB 600-483) will compete only with the specific reaction of antiserum with Human NFkB p50 (NFKB1). |
| Purity: | Whole antisera |
| Buffer: | Preservative: 0.01% Sodium Azide |
| Packaging: | 100 microlitres Liquid (sterile filtered) |
| Package Size: | 0.1 ml |
| Uses: | This antibody can be used for ELISA, GS, IP and Western Blot. In Western Blot, detects a band of approximately 50 kDa. Not tested in other applications. Recommended Starting Dilution:* ELISA: Use at an assay dependant dilution. GSA: Use at a concentra |
| Application Summary: | ELISA, GS, IP, WB |
| General References: | General / background references:Baldwin AS The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14:649-83 (1996). |
| Novus References: | 1. Hunter, R., et al. Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. Journal of Clinical Investigation. 114: 1504-1511, 2004. |
| Notes Main: | NFkB is formed as a homo- or hetero-dimer. Subunits include p50 (NFkB1), p65 (RelA), c-Rel, RelB and p52 (NFkB2). The classic NFkB form exists as a p50-p65 heterodimer and predominates in many cell types. Many of the possible combinatorial forms of homo- |