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| Catalog Code: | NB600-451 |
| Product Name: | Collagen Type III Antibody |
| Product Description: | Mouse Monoclonal anti-Collagen Type III (FH-7A) |
| Clone: | FH-7A |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Concentration: | 2.4 mg/ml |
| Immunogen: | Full-length native human protein (purified). |
| Specificity: | The antibody specifically recognizes native and denatured collagen type III. It does not recognize collagen types I, II, IV, V, VI and X. |
| Cross Reactivity: | Cross-reacts with Human and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Ascites Mouse ascites. |
| Uses: | Optimal dilutions should be determined by the end user. |
| Localization: | Extracellular matrix |
| Background: | HMG1 and HMG2, chromatin non-histone high mobility group proteins 1 and 2, are 27 and 25 kDa members of a family of proteins containing multiple HMG-boxes, conserved domains of 80 amino acids which mediate DNA binding of many proteins. HMG box domains recognize DNA structure, such as prebent, supercoiled or four way junction DNA, and non- specific DNA sequences. Both HMG1 and HMG2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMG1/2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites, such as steroid hormone receptors, p53, and Oct. HMG1/2 may serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription and replication. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Application Summary: | ELISA , Western Blot 1/100-1/1000, Immunohistochemistry-Frozen 1/4000 |
| Species Summary: | Hu, Rt, , |
| Alternate Names: | anti-COL3A1 antibody; anti-Collagen III alpha 1 chain precursor antibody; anti-Collagen III alpha 1 polypeptide antibody; anti-Collagen type III alpha 1 (Ehlers Danlos syndrome type IV autosomal dominant) antibody; anti-EDS4A antibody; anti-Fetal collagen antibody; anti-Type III collagen antibody |
| Package Size: | 0.1 ml |
| Preservative: | 15mM sodium azide |
| General References: | 1. Sanes JR et al. Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere. J Cell Biol 111:1685-99 (1990). 2. Superti-Furga A et al. Molecular defects of type III procollagen in Ehlers-Danlos syndrome type IV. Hum Genet 82:104-8 (1989). 3. Mayne R Preparation and applications of monoclonal antibodies to different collagen types. Clin Biochem 21:111-5 (1988). |
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