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| Catalog Code: | NB600-336 |
| Product Name: | c-myc Antibody |
| Product Description: | Rabbit Polyclonal anti-c-myc |
| Clonality: | Polyclonal |
| ListPrice: | 180 |
| Concentration: | 1 mg/ml |
| Immunogen: | Rabbits were immunized with c-myc (EQKLISEEDL)conjugated to KLH. Antibody was isolated by affinity chromatography using the peptide immobilized on solid support. |
| Specificity: | Antibody recognizes c-myc. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | This antibody can be used with ELISA, Western blot, immunohistochemistry and immunocytochemistry. |
| Localization: | Cytoplasmic and Nuclear |
| Background: | The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Host Name: | Rabbit |
| Buffer: | Phosphate Buffered Saline |
| Application Summary: | ELISA, Western Blot 1:1000-1:10000, Immunocytochemistry 1:100-1:400, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen 1:500, |
| Species Summary: | All |
| Alternate Names: | anti-c Myc antibody, anti-Cellular myelocytomatosis oncogene antibody, anti-Myc protein antibody, anti-Myc proto oncogene protein antibody, anti-Myc2 antibody, anti-Niard antibody, anti-Nird antibody, anti-Transcription factor p64 antibody, anti-v myc avian myelocytomatosis viral oncogene homolog antibody, anti-v myc myelocytomatosis viral oncogene homolog (avian) antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.09% Sodium Azide |
| Notes Main: | Blocking peptide is available for this antibody. The catalog number is NB600-336PEP. |
| Novus References: | 1. Sun et al., Rab6 Regulates Both ZW10/RINT-1- and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis. Mol.Biol.Cell 18 (10):4129-4142, 2007. 2. Pukatzki et al., Type VI secretion system translocates a phage tail spike-like protein into target cells where it cross-links actin. PNAS 104 (39):15508-15513, 2007. 3. Johnson et al., Functional and Therapeutic Analysis of Hepatitis C Virus NS3·4A Protease Control of Antiviral Immune Defense. J.Biol.Chem 282 (14):10792-10803, 2007. 4. Saito et al., Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. PNAS 104 (2):582-587, 2007. 5. Loo et al., Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. PNAS 103 (15):6001-6006, 2006. 6. Gong et al., Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. PNAS 103 (16):6154-6159, 2006. 7. Rengarajan,J., et al. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. PNAS, Jan 2008; 105: 264 - 269. 8. Silvestri, L., et al.Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood, Jan 2008; 111: 924 - 931. |
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