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| Catalog Code: | NB600-1534 |
| Product Name: | Fragilis Antibody |
| Product Description: | Rabbit Polyclonal anti-Fragilis - Germ Line Marker |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | A portion of amino acids 1-50 of mouse fragilis was used as the immunogen. |
| Cross Reactivity: | Expected to cross-react with Mouse (100% identity with immunogen) and Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Tested in peptide ELISA. |
| Localization: | Cell Membrane |
| Background: | Principal Names: Interferon-induced transmembrane protein 3(Ifitm3); Fragilis Official Gene Symbol: Ifitm3 Gen Bank Accession Number: NM_025378 Gene ID: 66141(Mouse) Gene Map Locus: 7F5 (Mouse) Fragilis is an IFN-induced transmembrane protein that belongs to the highly conserved fragilis protein family. It consists of an N-terminal signal sequence, 2 putative transmembrane domains, 3 potential phosphorylation sites and C-terminal Leucine-zipper. It is expressed in early embryos and nascent primordial germ cells and is associated with Germ cell specification and development. It is cell surface protein and might be important in mediating interactions amongst germ cells and their surrounding neighbours. It is also suggested that it might be involved in anti-proliferative signaling and homotypic cell adhesion. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| Application Summary: | ELISA |
| Species Summary: | Mu, Rt, |
| Package Size: | 0.1 mg |
| Preservative: | 0.05% Sodium Azide |
| Marker: | Germ Line Marker |
| General References: | General / background references:Saitou M et al. A molecular programme for the specification of germ cell fate in mice. Nature 418:293-300 (2002). |
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