| CatalogCode: | NB600-1495 |
| ProductName: | Fas antigen Antibody |
| Product Description: | Rabbit Polyclonal anti-Fas antigen |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide mapping near the carboxy terminal domain of human FAS. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 1 ml Affinity purified Rabbit antisera. |
| Uses: | IHC and IP: Use at an assay dependendent dilution. |
| Localization: | Type I membrane protein (isoform 1); Secreted (isoforms 2 to 6). |
| Control: | Jurkat and A-431 lysate. |
| Background: | CD95, also known as FAS or APO1, is a 36 kDa cell surface type I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS PAGE. CD95 is a member of the TNF receptor family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of CD95 Ligand to CD95 or crosslinking of CD95 by anti CD95 monoclonal antibodies leads to apoptosis of CD95 expressing cells. CD95 belongs to a subgroup of family members that have a death domain (DD) which contains 70 amino acids near the carboxyl terminal region of the molecule. The binding of adaptor molecules to this DD is responsible for transmitting the death signal for apoptosis. Stimulation of CD95 results in aggregation of its DD, leading to the recruitment of FADD and caspase 8 that together with the receptor form the death inducing signaling complex (DISC). CD95/CD95L is involved in the peripheral deletion of activated mature T cells at the end of the immune response and defects in this pathway predispose to autoimmune disorders. CD95 is also involved in killing of targets such as virus infected cells or cancer cells and killing of inflammatory cells at immune privileged sites. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Constituents: 0.2% Gelatin, PBS |
| ListPrice: | 295 |
| AppSummary: | IP, WB, IHC-P, IHC-Fr |
| SpeciesSummary: | Hu |
| ALTnames: | anti-ALPS1A antibody, anti-APO 1 antibody, anti-Apo 1 antigen antibody, anti-APO1 cell surface antigen antibody, anti-Apoptosis antigen 1 antibody, anti-Apoptosis APO1 antigen 1 antibody, anti-Apoptosis mediating surface antigen FAS antibody, anti-APT1 antibody, anti-CD 95 antibody, anti-CD95 antibody, anti-CD95 antigen antibody, anti-Fas (TNF receptor superfamily member 6) antibody, anti-FAS antibody, anti-FAS Antigen antibody, anti-FAS1 antibody, anti-FASL receptor antibody, anti-FASLG receptor antibody, anti-FASTM antibody, anti-TNF receptor superfamily member 6 antibody, anti-TNFR6 antibody, anti-TNFRSF6 antibody, anti-Tumor necrosis factor receptor superfamily member 6 antibody |
| ProteinTarget: | Fas antigen |
| PackageSize: | 1 ml |
| GeneralRef: | General / background references:Lin P et al. Tissue-specific regulation of Fas/APO-1/CD95 expression by p53. Int J Oncol 21:261-4 (2002). Takayama H et al. Frequent Fas gene mutations in testicular germ cell tumors. Am J Pathol 161:635-41 (2002). Hasumi K et al. Roles of tumor necrosis factor-alpha-receptor type 1 and Fas in the Helicobacter pylori-induced apoptosis of gastric epithelial cells. J Gastroenterol Hepatol 17:651-8 (2002). Redondo P et al. Fas and Fas ligand: expression and soluble circulating levels in cutaneous malignant melanoma. Br J Dermatol 147:80-6 (2002). Yukawa M et al. Systemic and local evidence of increased Fas-mediated apoptosis in ulcerative colitis. Int J Colorectal Dis 17:70-6 (2002). Okura T et al. Soluble Fas ligand and atherosclerosis in hypertensive patients. J Hypertens 20:895-8 (2002). Hara H et al. Accelerated production of nucleosome in cultured human mononuclear cells in untreated Graves' disease. Endocr J 49:189-94 (2002). Reichmann E The biological role of the Fas/FasL system during tumor formation and progression. Semin Cancer Biol 12:309-15 (2002). |
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