| CatalogCode: | NB600-1484 |
| ProductName: | APAF1 Antibody |
| Product Description: | Rabbit Polyclonal anti-APAF1 |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) (C terminal). |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 7 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | IHC-P: Ready to use. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. |
| Localization: | Cytoplasmic |
| Control: | Tested with testis cells. |
| Background: | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homolog of the key cell death gene CED 4 in C. elegans was identified recently from human and mouse and designated APAF1 for Apoptosis protease activating factor 1. APAF1 binds to Cytochrome c (APAF2) and Caspase 9 (APAF3), which leads to Caspase 9 activation. Activated Caspase 9 in turn cleaves and activates Caspase 3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. APAF1 can also associate with Caspase 4 and Caspase 8. APAF1 transcript is ubiquitously expressed in human tissues. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | Constituents: PBS, BSA. pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | IHC-P |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Apoptotic protease activating factor 1 antibody; anti-CED4 antibody; anti-KIAA0413 antibody |
| ProteinTarget: | APAF1, prediluted |
| PackageSize: | 7 ml |
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