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| Catalog Code: | NB600-1480 |
| Product Name: | Insulin Receptor Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-Insulin Receptor [Tyr1158] |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Synthetic phosphopeptide derived from the region that contains tyrosine 1158. |
| Cross Reactivity: | Cross-reacts with Human and Mouse. Expected to cross-react with Rat (100% identity with immunogen) due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 ml Immunogen affinity purified Rabbit antisera. |
| Uses: | IF: 1/50. |
| Localization: | Type I membrane protein |
| Background: | There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kD) and two beta (95 kD) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | Constituents: 0.2% BSA, PBS. pH 7.3 |
| Application Summary: | immunofluorescence |
| Species Summary: | Hu, Mu, |
| Alternate Names: | anti-IGFR1 antibody, anti-Insulin growth factor 1 receptor antibody, anti-CD221 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 0.05% Sodium Azide |
| Phosphorylated: | Tyr1158 |
| General References: | General / background references:Motley, E.D., et al. Insulin-induced Akt activation is inhibited by angiotensin II in the vasculature through protein kinase C-alpha. Hypertension 41:836-42 (2003).Wick, K.R., et al. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem. 278:8460-7 (2003).Hers, I., et al. Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes. Biochem J. 368:875-84 (2002).Pender, C., et al. Regulation of insulin receptor function by a small molecule insulin receptor activator. J Biol Chem. 277:43565-71 (2002). |
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more information: | company product webpage |