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| Catalog Code: | NB600-1468 |
| Product Name: | CA-125 Antibody |
| Product Description: | Mouse Monoclonal anti-CA-125 (X75) |
| Clone: | X75 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 1 mg/ml |
| Immunogen: | CA-125 purified from human ovarian carcinoma. |
| Specificity: | This antibody specifically reacts with human ovarian carcinoma cells. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | Western blot: use at a concentration of 1-5ug/ml after electrophoresing 20 ug of sample.Immunohistochemistry: use at a concentration of 1-5ug/ml.Flow Cytometry / FACS: assay dependent. Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.Dilute in PBS or medium which is identical to that used in the assay system. |
| Localization: | Cell Membrane |
| Background: | CA125/MUC16 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that CA125/MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000 kDa with smaller |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | PBS, pH7.2 |
| Application Summary: | flow cytometry / FACS analysis , immunohistochemistry 1-5 ug/ml, Western Blot 1-5 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-CA 125 antibody, anti-CA125 antibody, anti-CA125 ovarian cancer antigen antibody, anti-Cancer Antigen 125 antibody, anti-FLJ14303 antibody, anti-MUC 16 antibody, anti-MUC16 antibody, anti-Mucin 16 antibody, anti-Mucin 16 cell surface associated antibody, anti-Ovarian cancer antigen antibody, anti-Ovarian cancer related tumor marker CA125 antibody, anti-Ovarian carcinoma antigen CA125 antibody |
| Package Size: | 0.1 mg |
| Preservative: | No Preservative |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone: X75 - X306 For Sandwich ELISA pair this antibody with: NB120-10032 |
| Product References: | Heinzelmann-Schwarz VA <i>et al.</i> Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer. <i>Clin Cancer Res</i> <b>10</b>:4427-36 (2004). <PUBMED:15240533> |
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more information: | company product webpage |