| CatalogCode: | NB600-1448 |
| ProductName: | Insulin Antibody |
| Product Description: | Mouse Monoclonal anti-Insulin (7F8) |
| Clone: | 7F8 |
| Clonality: | Monoclonal |
| Immunogen: | Full length native protein (purified) (Human). |
| Specificity: | Human insulin |
| CrossReactivity: | This antibody cross-reacts with Human proinsulin, Cow insulin and Pig insulin.Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Mouse ascites. |
| Uses: | For detection of insulin in two-site enzyme immunoassay, this antibody can be used in conjunction with NB600-1449 (D4B8). This antibody recognises a different epitope than the anti-proinsulin (3A1). |
| Localization: | Secreted |
| Background: | Insulin is one of the major regulatory hormones of intermediate metabolism throughout the body. The biological actions of this hormone involve integration of carbohydrate, protein, and lipid metabolism. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Immunocytochemical investigations have localized insulin in the B cells of pancreatic islets of Langerhans. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of B cell origin such as insulinoma. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein A purified |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | PBS, pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | EIA |
| SpeciesSummary: | Bv, Hu, Po |
| ALTnames: | anti-Insulin precursor antibody |
| ProteinTarget: | Insulin |
| PackageSize: | 0.1 mg |
| NotesMain: | K<sub>ass</sub> for clone 7F8 is 7.5 x 10<sup>9</sup>M<sup>-1</sup> |