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| Catalog Code: | NB600-1432 |
| Product Name: | Caspase 12 Antibody |
| Product Description: | Rat Monoclonal anti-Caspase 12 (14F7) |
| Clone: | 14F7 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 2 mg/ml |
| Immunogen: | Recombinant fragment: GPQKICTPSS PSESKRKVEDD EMEVNAGLAH ESHLM LTAPH GLQSSEVQDTL KLCPRDQFCK IKTERAKEIY PVMEKEGRTRL ALIICNKKFDY LFDRDNADTDI LNMQELLENLG YSVVLKENLTA QEMETELMQFA GRPEHQSSDST FLVFMSHGIL EGICGVKHRNK KPDVLHDDTIF KIFNNSNCRSL RNKPKILIMQA CRGRYNGTIWV STNKGIATAD, corresponding to amino acids 95-318 of Mouse Caspase 12. |
| Cross Reactivity: | Cross-reacts with Human, Mouse and Rat.Not yet tested in other species. |
| Packaging: | 0.05 ml IgG purified Rat ascites. |
| Uses: | ICC: 4% paraformaldehyde-fixed, paraffin-embedded). WB: Dilution determined by using a whole cell extract of human hepatocellular carcinoma HepG2 cells. Predicted molecular weight: 50 kDa. This antibody recognizes the full length and possibly the truncated p20 subunit of Caspase 12.Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Endoplasmic reticulum |
| Purity: | IgG purified |
| Isotype: | IgG2a |
| Host Name: | Rat |
| Buffer: | Constituents: 0.01M PBS. pH 7.4 |
| Application Summary: | Western Blot 1 - 2 ug/ml, Immunocytochemistry |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | Anti-Apoptosis related cysteine protease antibody, Anti-CASP 12 antibody, Anti-casp12 antibody, Anti-CASP12P1 antibody, Anti-Caspase 12 psuedogene 1 antibody, Anti-Caspase12 antibody, Anti-UNQ9415 antibody |
| Package Size: | 0.05 ml |
| Preservative: | 15mM Sodium Azide |
| Notes Main: | For continuous use, store at 2-8 degrees C for up to one month.If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours. |
| General References: | General / background references:Nakagawa T et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103 (2000). Nakagawa T & Yuan J Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150:887-94 (2000). Thornberry NA & Lazebnik Y Caspases: enemies within. Science 281:1312-6 (1998). Cryns V & Yuan J Proteases to die for. Genes Dev 12:1551-70 (1998). Kidd VJ Proteolytic activities that mediate apoptosis. Annu Rev Physiol 60:533-73 (1998). Cohen GM Caspases: the executioners of apoptosis. Biochem J 326 ( Pt 1):1-16 (1997). |
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