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| Catalog Code: | NB600-1403 |
| Product Name: | Bcl 10 Antibody |
| Product Description: | Mouse Monoclonal anti-Bcl 10 (151) |
| Clone: | 151 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Concentration: | 2.1 mg/ml |
| Immunogen: | Recombinant full length protein (Human). |
| Epitope: | The epitope recognized by the antibody resides within amino acids 122-168 of human Bcl 10 molecule. |
| Cross Reactivity: | Cross-reacts with Human.Not yet tested in other species. |
| Packaging: | 0.1 ml Protein A purified Mouse ascites. |
| Uses: | IHC-P: Perform heat mediated antigen retrieval before commencing with IHC staining protocol. WB: Detects bands of approximately 20, 32 and 37 kDa. |
| Localization: | Cytoplasmic. Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. |
| Background: | Bcl 10, also designated as CIPER, mE10, cE10, CARMEN, and CLAP, is an N-terminal CARD (Caspase Recruitment Domain) containing protein. It is a cellular homologue of the equine herpesvirus-2 protein E-10 (vCLAP). Bcl 10 was implicated in the regulation of apoptosis by interacting with caspase 9, enhancing procaspase 9 processing, and triggering its activation when overexpressed in the cell. Bcl 10 cellular overexpression induces JNK, p38, and NF-kappaB activation. Deregulation of Bcl 10 expression was also demonstrated to be involved in cellular oncogenesis. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG1 |
| Host Name: | Mouse |
| Buffer: | Constituents: 0.01M PBS. pH 7.4 |
| Application Summary: | ELISA , Western Blot 1-2 ug/ml, Immunohistochemistry-Paraffin |
| Species Summary: | Hu, |
| Alternate Names: | Anti-B cell lymphoma/leukemia10 antibody; Anti-B cell CLL/lymphoma 10 antibody; Anti-B cell lymphoma/leukemia10 antibody; Anti-Bcl-10 antibody; Anti-Bcl 10 antibody; Anti-c E10 antibody; Anti-CARD containing apoptotic signaling protein antibody; Anti-CARD containing molecule enhancing NF kappa B antibody; Anti-CARD containing molecule enhancing NF kB antibody; Anti-CARD containing molecule enhancing NFkB antibody; Anti-CARD containing proapoptotic protein antibody; Anti-CARD like apoptotic protein antibody; Anti-CARMEN antibody; Anti-Caspase recruiting domain containing protein antibody; Anti-cCARMEN antibody; Anti-cE 10 antibody; Anti-cE10 antibody; Anti-CED 3/ICH 1 prodomain homologous E10 like regulator antibody; Anti-CED3/ICH1 prodomain homologous E10 like regulator antibody; Anti-Cellular E10 antibody; Anti-Cellular homolog of vCARMEN antibody; Anti-CIPER antibody; Anti-CLAP antibody; Anti-hCLAP antibody; Anti-Mammalian CARD containing adapter molecule E10 antibody; Anti-mE 10 antibody; Anti-mE10 antibody |
| Package Size: | 0.1 ml |
| Preservative: | 15mM Sodium Azide |
| General References: | General / background references:Ye H et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157:1147-54 (2000). Du MQ et al. BCL10 gene mutation in lymphoma. Blood 95:3885-90 (2000). Willis TG et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96:35-45 (1999). |
| Novus References: | 1. Bhattacharyya S, Gill R, Chen ML, et al. Toll-like Receptor 4 Mediates Induction of the Bcl10-NF{kappa}B-Interleukin-8 Inflammatory Pathway by Carrageenan in Human Intestinal Epithelial Cells. J Biol Chem. April 18, 2008;283(16):10550-8. |
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