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| Catalog Code: | NB600-1400 |
| Product Name: | DR6 Antibody |
| Product Description: | Rabbit Polyclonal anti-DR6 |
| Clonality: | Polyclonal |
| ListPrice: | 345 |
| Concentration: | 0.2 mg/ml |
| Immunogen: | The antibody was raised against the cytoplasmic domain (amino acids 371-655) of human DR6 protein. |
| Specificity: | A ~66 kDa band is observed. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.05 mg protein A purified Rabbit antisera. |
| Uses: | WB: Detects a band of approximately 66 kDa (predicted molecular weight: 79 kDa). |
| Localization: | Cell Membrane |
| Background: | Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel death domain containing receptor was recently identified and designated DR6 (for death receptor 6) (1). The extracellular domain of DR6 contains four TNFR-like cysteine rich motifs that are related to those of osteoprotegerin (OPG) (2) and TNFR2 (3) with 36% and 42% amino acid identities, respectively. The death domain of DR6 (amino acids 428-494) located adjacent to the transmembrane domain is most related to TNFR1 (27.2%) and least to DR5 (19.7%) (1). |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG2 |
| Host Name: | Rabbit |
| Buffer: | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| Application Summary: | Western Blot 1 - 2 ug/ml |
| Species Summary: | Hu, |
| Alternate Names: | anti-BM018 antibody, anti-Death receptor 6 antibody, anti-TNFR related death receptor 6 antibody, anti-Tumor necrosis factor receptor superfamily member 21 antibody, anti-Tumor necrosis factor receptor superfamily member 21 precursor antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.02% Sodium Azide |
| Notes Main: | Keep on ice when not in storage. |
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