| CatalogCode: | NB600-1308 |
| ProductName: | Granzyme B Antibody |
| Product Description: | Mouse Monoclonal anti-Granzyme B (GZB01) |
| Clone: | GZB01 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant full length protein (Human). |
| Specificity: | This antibody reacts with a 32 kD protein. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.5 ml Tissue culture supernatant Mouse ascites. |
| Uses: | Immunohistochemistry (formalin fixed paraffin embedded / frozen sections): use at a dliution of 1/10 - 1/25 in an ABC method.Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. |
| Localization: | Cytoplasmic granules of cytolytic T-Lymphocytes |
| Control: | Suitable tissue control sections for Immunohistochemistry:Hodgkin?s lymphoma. |
| Background: | Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Tissue culture supernatant |
| Isotype: | IgG2a |
| Host_Name: | Mouse |
| Buffer: | Tissue culture supernatant with sodium azide |
| ListPrice: | 295 |
| AppSummary: | IHC-Fr, IHC-P |
| SpeciesSummary: | Hu |
| ALTnames: | anti-C11 antibody, anti-Cathespin G Like 1 antibody, anti-CCPI antibody, anti-CGL 1 antibody, anti-CGL1 antibody, anti-CSP B antibody, anti-CSPB antibody, anti-CTLA 1 antibody, anti-CTLA1 antibody, anti-CTSGL 1 antibody, anti-CTSGL1 antibody, anti-Cytotoxic serine protease B antibody, anti-Cytotoxic T Lymphocyte Associated Serine Esterase 1 antibody, anti-Cytotoxic T lymphocyte proteinase 2 antibody, anti-EC 3.4.21.79 antibody, anti-Fragmentin 2 antibody, anti-Fragmentin2 antibody, anti-Granzyme 2 antibody, anti-Granzyme2 antibody, anti-GranzymeB antibody, anti-GRB antibody, anti-GZMB antibody, anti-HLP antibody, anti-Human lymphocyte protein antibody, anti-Lymphocyte protease antibody, anti-Protease Serine B antibody, anti-SECT antibody, anti-T cell serine protease 1 3E antibody |
| ProteinTarget: | Granzyme B |
| PackageSize: | 0.5 ml |
| GeneralRef: | General / background references:Andrade F et al. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 8:451-60 (1998). Cho MS et al. Granzyme B immunoreactivity in T/natural killer cell lymphomas. Yonsei Med J 38:285-93 (1997). de Bruin PC et al. Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype. Histopathology 31:313-7 (1997). |
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