| CatalogCode: | NB600-1198 |
| ProductName: | Huntingtin Antibody |
| Product Description: | Mouse Monoclonal anti-Huntingtin (HDC8A4) |
| Clone: | HDC8A4 |
| Clonality: | Monoclonal |
| Immunogen: | Recombinant fragment, corresponding to amino acids 2703-2911 of Huntingtin. |
| Specificity: | This antibody reacts with an epitope corresponding to the HDC region (2703 - 2911 amino acids) of the huntingtin protein |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 0.1 mg IgG purified Mouse ascites. |
| Uses: | Immunohistology - frozen (paraffin not tested)Western blotting - detects a 350kD band on western blots but also detects smaller degradation products of huntingtin. This clone recognizes both denatured and native huntingtin in human brain.Immunoprecipitation |
| Localization: | Cytoplasmic |
| Background: | The combined use of clones HDC8A4, HDB4E10 and HDA3E10 demonstrate that huntingtin is enriched in neuronal cells in the brain. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Mouse |
| Buffer: | n/a |
| ListPrice: | 340 |
| AppSummary: | IHC-Fr, IP, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-HD antibody, anti-HD protein antibody, anti-HDH antibody, anti-HTT antibody, anti-HUNTINGTON CHOREA antibody, anti-Huntington's disease protein homolog antibody, anti-IT15 antibody, anti-ZHD antibody |
| ProteinTarget: | Huntingtin |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Wilkinson FL et al. Localization of rabbit huntingtin using a new panel of monoclonal antibodies. Brain Res Mol Brain Res 69:10-20 (1999). |