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| Catalog Code: | NB600-1138 |
| Product Name: | Cyclin A Antibody |
| Product Description: | Rabbit Polyclonal anti-Cyclin A |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Synthetic peptide: HSKYHSVSLLNPPETLSV (Mouse) (C terminal). |
| Specificity: | Reacts with cyclin A2 |
| Cross Reactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 1 ml IgG purified Rabbit antisera. |
| Background: | Cyclins are regulatory subunits of the cyclin-dependent kinases (cdks) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdks. These cyclin / cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S phase and passage through G2 phase. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS with 0.1% sodium azide |
| Application Summary: | immunohistochemistry-Fr, immunoprecipitation, Western Blot |
| Species Summary: | Hu, Mu, Rt, |
| Alternate Names: | anti-CCN1 antibody, anti-Cyclin A2 antibody |
| Package Size: | 1 ml |
| Preservative: | 0.1% Sodium Azide |
| General References: | General / background references:Goldstone S et al. Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene 20:921-32 (2001). Liu D et al. A role for cyclin A1 in the activation of MPF and G2-M transition during meiosis of male germ cells in mice. Dev Biol 224:388-400 (2000). Kishimoto T & Okumura E In vivo regulation of the entry into M-phase: initial activation and nuclear translocation of cyclin B/Cdc2. Prog Cell Cycle Res 3:241-9 (1997). Desdouets C et al. Cyclin A: function and expression during cell proliferation. Prog Cell Cycle Res 1:115-23 (1995). Thron CD Theoretical dynamics of the cyclin B-MPF system: a possible role for p13suc1. Biosystems 32:97-109 (1994). Hoffmann I et al. Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J 12:53-63 (1993). Brechot C Oncogenic activation of cyclin A. Curr Opin Genet Dev 3:11-8 (1993). Bandara LR et al. Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1. J Cell Sci Suppl 16:77-85 (1992). Baratte B et al. Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase. Anticancer Res 12:873-80 (1992). |
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