| CatalogCode: | NB600-1132 |
| ProductName: | Ghrelin Antibody |
| Product Description: | Chicken Polyclonal anti-Ghrelin |
| Clonality: | Polyclonal |
| Immunogen: | RKESKKPPAKLQ, corresponding to amino acids 38-49 of Ghrelin. |
| Epitope: | C12 region of Ghrelin. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat.Expected to cross-react with Cat (100% identity with immunogen), Dog (100% identity with immunogen), Gerbil (100% identity with immunogen), Macaque Monkey (100% identity with immunogen) and Pig (90% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Uses: | WB: Predicted molecular weight: 13 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Secreted |
| Background: | Ghrelin was originally discovered as a preprohormone that stimulates the release of growth hormone from the anterior pituitary. Recent studies have shown that ghrelin, in concert with other hormones, helps to control both appetite and energy balance.The synthesis of ghrelin takes place predominantly in epithelial cells of the stomach, although it is also produced in smaller quantities in the placenta, kidney, pituitary and hypothalamus.Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release from the pituitary. It has an appetite stimulating effect, induces adiposity, and stimulates gastric acid secretion, and it is involved in growth regulation. Ghrelin is synthesized as a preprohormone (13kDa), then proteolytically processed to yield a 28 amino acid peptide (3kDa). Obestatin, an appetite suppressing peptide hormone, is also produced in the process. An interesting and unique modification is imposed on the ghrelin hormone during synthesis in the form of octanoic acid bound to one of its amino acids. This modification is necessary for biological activity. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 285 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Ghrl antibody, anti-Growth hormone secretagogue antibody, anti-Growth-hormone releasing protein antibody, anti-Motilin-related peptide antibody, anti-M46 protein antibody, anti-Mtlrp antibody, anti-MTLRPAP antibody, anti-Appetite-regulating hormone antibody |
| ProteinTarget: | Ghrelin |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Wortley KE et al. Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A 101:8227-32 (2004). |
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