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| Catalog Code: | NB600-1089 |
| Product Name: | TLR7 Antibody |
| Product Description: | Rabbit Polyclonal anti-TLR7 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Concentration: | 0.5 mg/ml |
| Immunogen: | Synthetic peptide: LKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKN conjugated to KLH, corresponding to amino acids 650-700 of Human TLR7. BLAST 'LKLEELDISK NSLSFLPSGV FDGMPPNLKN LSLAKNGLKS |
| Cross Reactivity: | Expected to cross-react with Human (100% identity with immunogen) and Rat (86% identity with immunogen) due to sequence homology. Not yet tested in other species. |
| Packaging: | 0.05 mg protein G purified Rabbit antisera. |
| Uses: | FACS: Use at a concentration of 0.5 - 2 ug/1 x 10<sup>6</sup> Ramos cells. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Type I membrane protein (By similarity). |
| Background: | The Toll like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL 1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs characterized so far activate the MyD88/interleukin 1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1 10) have been described. Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | PBS |
| Application Summary: | flow cytometry / FACS analysis |
| Alternate Names: | anti-PRO285 antibody, anti-TLR 7 antibody, anti-Toll like receptor 7 antibody, anti-UNQ248 antibody |
| Package Size: | 0.05 mg |
| Preservative: | 0.05% Sodium Azide |
| General References: | General / background references:Chuang T & Ulevitch RJ Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta 1518:157-61 (2001). Muzio M et al. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J Exp Med 187:2097-101 (1998). Medzhitov R & Janeway CA Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295-8 (1997). |
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more information: | company product webpage |