| CatalogCode: | NB600-1070 |
| ProductName: | ERK1 + ERK2 Antibody |
| Product Description: | Rabbit Polyclonal anti-ERK1 + ERK2 [Thr202+Tyr204] |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1 and Erk2) |
| Specificity: | This antibody recognises ERK1 phosphorylated at Thr202 and ERK1 phosphorylated at Tyr204. |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.1 ml Whole Rabbit antisera. |
| Uses: | Predicted molecular weight: 43 kDa. |
| Localization: | Cell Membrane |
| Control: | NIH3T3 cell lysates stimulated with PDGF. |
| Background: | ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Whole antisera |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | 50% Glycerol, PBS |
| ListPrice: | 295 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-ERT1 antibody, anti-Extracellular signal regulated kinase 1 antibody, anti-Extracellular signal regulated kinase 2 antibody, anti-MAP kinase 2 antibody, anti-MAPK 2 antibody, anti-MAPK 3 antibody, anti-Mitogen activated protein kinase 1 antibody, anti-Mitogen activated protein kinase 3 antibody, anti-p42MAPK antibody, anti-p44ERK1 antibody, anti-p44MAPK antibody, anti-PRKM 1 antibody, anti-PRKM 2 antibody, anti-PRKM 3 antibody, anti-Protein kinase mitogen activated 1 antibody, anti-Protein kinase mitogen activated 2 antibody, anti-Protein kinase mitogen activated 3 antibody, anti-Protein tyrosine kinase ERK 2 antibody |
| ProteinTarget: | ERK1 + ERK2 (phospho T202/183 + Y204/185) |
| PackageSize: | 0.1 ml |
| GeneralRef: | General / background references:Smalley KS A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 104:527-32 (2003). Johnson GL & Lapadat R Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-2 (2002). Kolch W Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351 Pt 2:289-305 (2000). |
| Phosphorylated: | Thr202+Tyr204 |
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