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| Catalog Code: | NB600-1062 |
| Product Name: | Pi 3 Kinase Antibody |
| Product Description: | Rabbit Polyclonal anti-Pi 3 Kinase |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | 20 amino acid C-terminal peptide to Phosphoinositide 3 Kinase p110 delta. |
| Specificity: | Binds to a 110 Kd protein. Not likely to cross react with other isoforms due to sequence dissimilarity. |
| Cross Reactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | ELISA: Use at a dilution of 1/75000. ICC: Use at a dilution of 1/400. WB: Use at a dilution of 1/3000. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Background: | PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p110. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K. Four isoforms of p110 has been found; the alpha, beta, gamma, and the delta subunit. The delta isoform is predominantly expressed in leukocytes and has been shown to interact with p85 and GTP-bound Ras via its SH2/SH3 domain. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | KHPO4, 1mg/ml BSA, 0.1% sodium azide, pH7.4 |
| Application Summary: | ELISA , Western Blot , Immunocytochemistry |
| Species Summary: | Hu, |
| Alternate Names: | anti-p110D antibody, anti-p110delta antibody, anti-Phosphatidylinositol 3 kinase catalytic delta polypeptide antibody, anti-Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit delta isoform antibody, anti-Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit delta isoform antibody, anti-Phosphoinositide 3 kinase B antibody, anti-Phosphoinositide 3 kinase C antibody, anti-Phosphoinositide 3 kinase catalytic delta polypeptide antibody, anti-PI3 kinase p110 subunit delta antibody, anti-PI3K antibody, anti-PIK3CD antibody, anti-PK3CD antibody, anti-PtdIns 3 kinase p110 antibody |
| Package Size: | 0.1 mg |
| Preservative: | 0.01% Sodium Azide |
| General References: | This product has been used in:Vanhaesebroeck B et al. P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A 94:4330-5 (1997). |
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more information: | company product webpage |