| CatalogCode: | NB600-1022 |
| ProductName: | Bcl-x Antibody |
| Product Description: | Rabbit Polyclonal anti-Bcl-x |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide (Human) (N terminal). |
| Specificity: | Reacts with Bcl-x S/L |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse. Not yet tested in other species. |
| Packaging: | 1 ml IgG purified Rabbit antisera. |
| Localization: | Mitochondrial membranes and perinuclear envelope |
| Background: | The protein encoded by this gene belongs to the Bcl2 protein family. Bcl2 family members form hetero or homodimers and act as anti or pro apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | IgG purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS with 0.1% sodium azide |
| ListPrice: | 295 |
| AppSummary: | IHC-P, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Apoptosis regulator Bcl X antibody, anti-Bcl 2 like 1 antibody, anti-Bcl 2 like 1 protein antibody, anti-Bcl xL antibody, anti-BCL XL/S antibody, anti-Bcl xS antibody, anti-Bcl2 like1 antibody, anti-BCL2L antibody, anti-BCL2L1 antibody, anti-Bclx antibody, anti-DKFZp781P2092 antibody |
| ProteinTarget: | Bcl-x |
| PackageSize: | 1 ml |
| GeneralRef: | General / background references:Coldwell MJ et al. The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene 20:4095-100 (2001). Fridman JS et al. Cytochrome c depletion upon expression of Bcl-XS. J Biol Chem 276:4205-10 (2001). Wei MC et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727-30 (2001). Bae J et al. Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Apoptosis 6:319-30 (2001). Huang Z Bcl-2 family proteins as targets for anticancer drug design. Oncogene 19:6627-31 (2000). Eversole-Cire P et al. Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death. Invest Ophthalmol Vis Sci 41:1953-61 (2000). Lindenboim L et al. Bcl-xS and Bax induce different apoptotic pathways in PC12 cells. Oncogene 19:1783-93 (2000). Reed JC Double identity for proteins of the Bcl-2 family. Nature 387:773-6 (1997). Yang E et al. Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-91 (1995). |
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