| CatalogCode: | NB600-1005 |
| ProductName: | LYVE1 Antibody |
| Product Description: | Rabbit Polyclonal anti-LYVE1 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant full length protein produced in insect cells, corresponding to amino acids 24-232 of Human LYVE1 and is fused to a C-terminal His-tag (6xHis). |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg protein A purified Rabbit antisera. |
| Uses: | IHC: Originally, it has not been tested on formalin-fixed tissue sections. However, recently one of our customers has used it successfully on this type of application (see review). Predicted molecular weight: 39 kDa. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Plasma membrane |
| Background: | LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS. pH 7.4 |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB, IHC-Fr |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Extracellular link domain containing 1 antibody; anti-HAR antibody; anti-hyaluronic acid receptor antibody; anti-lymphatic vessel endothelial hyaluronan receptor 1 antibody; anti-LYVE-1 antibody; anti-XLKD1 antibody |
| ProteinTarget: | LYVE1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Jackson DG The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med 13:1-7 (2003). Carriera et al Cancer Research 61:8079 (2001).Sleeman JP et al. Markers for the lymphatic endothelium: in search of the holy grail? Microsc Res Tech 55:61-9 (2001). Makinen T et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 20:4762-73 (2001). |