| CatalogCode: | NB500-581 |
| ProductName: | ZAP70 Antibody |
| Product Description: | Rabbit Polyclonal anti-ZAP70 |
| Clonality: | Polyclonal |
| Immunogen: | Bacterially expressed fusion protein representing C terminal part (160 amino acids) of human ZAP70. |
| Specificity: | C-terminal part of human ZAP-70 protein tyrosine kinase. |
| CrossReactivity: | Reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg purified antisera |
| Uses: | This antibody can be used for Western blot. Predicted molecular weight: 70 kDa. Not tested in other applications.Recommended starting dilutions:*WB: 1/1000 *Optimal dilutions/concentrations should be determined by the end user. |
| Background: | ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Mutations in ZAP70 gene results in a form of Severe Combined Immunodeficiency Syndrome (SCID) in humans. ZAP70 expression also defines a subset of Chronic Lymphocytic Leukemia (CLL) in patients with unmutated Ig gene and poor clinical course. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Protein A purified |
| Host_Name: | Rabbit |
| Buffer: | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-70 kDa zeta associated protein antibody, anti-Selective T cell defect antibody, anti-SRK antibody, anti-STD antibody, anti-Syk related tyrosine kinase antibody, anti-Truncated ZAP kinase antibody, anti-Tyrosine protein kinase ZAP70 antibody, anti-TZK antibody, anti-Zeta chain associated protein kinase 70kDa isoform 1 antibody, anti-Zeta chain associated protein kinase 70kDa isoform 2 antibody |
| ProteinTarget: | ZAP70 |
| PackageSize: | 0.1 mg |
| GeneralRef: | Chan AC, Irving BA, Fraser JD, Weiss A: The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci USA 88(20), 9166 (1991). |