| CatalogCode: | | NB500-530 |
| ProductName: | | Kinesin Antibody |
| Product Description: | | Mouse Monoclonal anti-Kinesin (KN-02) |
| Clone: | | KN-02 |
| Clonality: | | Monoclonal |
| Immunogen: | | Enriched fraction of porcine brain kinesin. |
| Specificity: | | The antibody reacts with heavy chain of conventional kinesin associated with vesicles and with lower affinity with denaturated molecule. The antibody does not react with kinesin bound to taxol-stabilized microtubules. |
| CrossReactivity: | | Cross-reacts with Human, Mouse, Rat and Pig.Not yet tested in other species. |
| Packaging: | | 0.1 mg IgM purified Mouse ascites. |
| Uses: | | Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | | Microtubules |
| Background: | | Kinesin belongs to the group of motor proteins known to convert chemical energy released from ATP into mechanical energy. Conventional kinesin, member of the kinesin superfamily comprising more than 100 proteins, is involved in the anterograde vesicle transport inneuronal cells. Kinesin purified from mammalian brain homogenates is a heterotetramer consisting of two heavy (120 to 130 kDa) and two light chains (60 to 70 kDa), resulting in a molecular mass about 400 kDa. Each heavy chain contains an N terminal globular motordomain with both a microtubule binding site and an ATPase active center, stalk region responsible for heavy chain dimerization and finally C terminal globular tail domain, which is implicated in cargo binding. Light chains may have a regulatory function. |
| Purity: | | IgM purified |
| Isotype: | | IgM |
| Host_Name: | | Mouse |
| Buffer: | | PBS, pH 7.4 |
| ListPrice: | | 285 |
| AppSummary: | | ICC |
| SpeciesSummary: | | Hu, Mu, Po, Rt |
| ALTnames: | | anti-KIF5B antibody, anti-Kinesin 1 (110-120kD) antibody, anti-Kinesin family member 5B antibody, anti-Kinesin heavy chain ubiquitous antibody, anti-KINH antibody, anti-KNS1 antibody, anti-Ubiquitous kinesin heavy chain antibody, anti-UKHC antibody |
| ProteinTarget: | | Kinesin |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | General / background references:Macurek L et al. Monoclonal antibodies KN-02 and KN-03 against the heavy chain of kinesin. Hybrid Hybridomics 21:457-62 (2002). |
| more information: | | company product webpage |
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