| CatalogCode: | NB500-515 |
| ProductName: | STAT1 Antibody |
| Product Description: | Mouse Monoclonal anti-STAT1 (PSM1) [Ser727] |
| Clone: | PSM1 |
| Clonality: | Monoclonal |
| Immunogen: | Synthetic peptide: DNLLPMSpPEEFDE, corresponding to amino acids 721-733 of Human STAT 1. |
| Specificity: | The antibody recognizes STAT 1 (91 kDa) activated by phosphorylation at Ser727. |
| CrossReactivity: | Cross-reacts with Human. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Mouse ascites. |
| Uses: | WB: Detects a band of approximately 91 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5.Specific functions of the STAT proteins are poorly defined at this time. They are thought to be involved in a variety of systems including antiviral responses and cell transformation. STAT1 deficient knock-out mice are unable to induce IFN regulated genes and are extremely susceptible to viral diseases. After phosphorylation, STAT1 and STAT2 form heterodimers that function as more potent inducers of transcription than the STAT1 homodimer.STAT1 is known to associate with the transcription factors p48, Sp1, and p300. STAT1 is activated by peptide hormones, growth factors and cytokines, particularly cytokines of the interferon family. STAT1 alpha and STAT1 beta isoforms arise by alternative splicing of a single gene. The only difference between the two proteins is that STAT1 beta lacks 38 carboxy terminal amino acids. Contained within these 38 terminal amino acids of STAT1 alpha is a critical serine residue (Ser 727) whose phosphorylation is required for maximal transcription activity induced by IFN gamma. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | Preservative: 15mM Sodium AzideConstituents: PBS. pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-DKFZp686B04100 antibody, anti-ISGF 3 antibody, anti-Signal transducer and activator of transcription 1 91kDa antibody, anti-Signal transducer and activator of transcription 1 alpha/beta antibody, anti-Signal Transductor and Activator of Transcription 1 antibody, anti-STAT 1 antibody, anti-STAT 91 antibody, anti-STAT91 antibody, anti-Transcription factor ISGF 3 components p91 p84 antibody |
| ProteinTarget: | STAT 1 |
| PackageSize: | 0.1 mg |
| Phosphorylated: | Ser727 |
order or
more information: | company product webpage |
| request information: |
|
|