| CatalogCode: | NB500-322 |
| ProductName: | Cytokeratin 7 Antibody |
| Product Description: | Mouse Monoclonal anti-Cytokeratin 7 (C-68) |
| Clone: | C-68 |
| Clonality: | Monoclonal |
| Immunogen: | HeLa cell preparation (cervix carcinoma) (Human). |
| Specificity: | Cytokeratin peptide 7 (54 kDa). The strong reactivity is observed on human tissues, weaker staining on other tested mammalian species. |
| CrossReactivity: | Cross-reacts with Human and weakly with Cow, Dog, Pig and Sheep. Not yet tested in other species. |
| Packaging: | 0.1 mg Affinity purified Mouse ascites. |
| Uses: | IHC-Fr: The antibody strongly stains most simple epithelia except for stomach, small intestine and colon mucosa, hepatocytes and renal tubules. WB: Detects a band of approximately 54 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 - 7.8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Affinity purified |
| Isotype: | IgG1 |
| Host_Name: | Mouse |
| Buffer: | PBS pH 7.4 |
| ListPrice: | 285 |
| AppSummary: | IHC-Fr, WB |
| SpeciesSummary: | Bv, Ca, Hu, Po, Sh |
| ALTnames: | anti-ck7 antibody, anti-K2C7 antibody, anti-Keratin 55k type ii cytoskeletal antibody, anti-Keratin 7 antibody, anti-Keratin simple epithelial type 1 k7 antibody, anti-Keratin type ii cytoskletal 7 antibody, anti-KRT7 antibody, anti-mgc3625 antibody, anti-Sarcolectin antibody, anti-SCL antibody, anti-Type ii mesothelial keratin k7 antibody |
| ProteinTarget: | Cytokeratin 7 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Bartek J <i>et al.</i> A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. <i>J Pathol</i> <b>164</b>:215-24 (1991). 2. Vojtesek B <i>et al.</i> A panel of monoclonal antibodies to keratin no. 7: characterization and value in tumor diagnosis. <i>Neoplasma</i> <b>37</b>:333-42 (1990). |
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