| CatalogCode: | NB500-206 |
| ProductName: | Caspase 7 Antibody |
| Product Description: | Mouse Monoclonal anti-Caspase 7 |
| Clonality: | Monoclonal |
| Immunogen: | Full-length recombinant human Caspase 7 protein |
| Specificity: | Specific for Caspase 7. |
| CrossReactivity: | Recognizes human, rat, and mouse Caspase 7.
Other species have not been tested. |
| Packaging: | 0.1 ml Ascites Mouse ascites. |
| Uses: | NB 500-206 may be used in Western analysis where a band representing caspase 7 is seen at ~ 35 kDa.The investigator should determine the optimal working dilution for a specific application. |
| Localization: | Cytoplasmic |
| Control: | HeLa and Jurkat whole cell extracts. |
| Background: | Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Ascites |
| Isotype: | IgG1 kappa |
| Host_Name: | Mouse |
| Buffer: | Ascitic fluid |
| ListPrice: | 285 |
| NovusRef: | 1. Blanc-Brude, O., et al. Therapeutic Targeting of the Survivin Pathway in Cancer: Initiation of Mitochondrial Apoptosis and Suppression of Tumor-associated Angiogenesis. Clinical Cancer Research. 9:2683-2692, 2003. |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Apoptosis related cysteine peptidase antibody; anti-Apoptosis Related Cysteine Protease antibody; anti-Apoptotic Protease MCH3 antibody; anti-CASP 7 antibody; anti-CMH1 antibody; anti-ICE LAP3 antibody; anti-ICE like Apoptotic Protease 3 antibody; anti-MCH3 antibody |
| ProteinTarget: | Caspase 7 |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Kirsch, D., et al. Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c. JBC, 274(30): 21155-21161, 1999. 2. Fearnhead, H.O., et al. Oncogene-dependent Apoptosis is Mediated by Caspase-9. PNAS, USA, 95: 13664-13669, 1998. |
| NotesMain: | Clone: Mch3 1-1-11 |
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