| CatalogCode: | NB500-179 |
| ProductName: | TPX2 Antibody |
| Product Description: | Rabbit Polyclonal anti-TPX2 |
| Clonality: | Polyclonal |
| Immunogen: | Produced by immunizing rabbits with a recombinant segment of the C-terminal domain of the human protein. |
| Specificity: | This antibody is specific for TPX2. |
| CrossReactivity: | Reactive to most mammalian species. |
| Packaging: | 0.1 ml Whole antisera Rabbit antisera. |
| Uses: | A band at ~100 kDa can be detected by Western blot. May also be used for immunoprecipitation and immunofluoresence. The investigator should determine the optimal working dilution for a specific application. |
| Localization: | Nuclear. Staining of non-mitotic cells and cell cycle-dependent changes in abundance peaking at G2/M phase. |
| Background: | TPX2 is a microtubule cross-linking protein involved in spindle formation. During mitosis it is strictly associated with the mitotic spindle, whereas during phases S and G2, it is diffusely distributed throughout the nucleus. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host_Name: | Rabbit |
| ListPrice: | 285 |
| NovusRef: | 1. Xia F, Lee CW, Altieri DC. Tumor Cell Dependence on Ran-GTP-Directed Mitosis. Cancer Res. March 15, 2008;68(6):1826-33. |
| AppSummary: | IF, IP, WB |
| SpeciesSummary: | Hu, Ma, Mu, Rt |
| ALTnames: | anti-Restricted expression proliferation associated protein 100 antibody, anti-p100 antibody, anti-Differentially expressed in cancerous and noncancerous lung cells 2 antibody, anti-DIL-2 antibody, anti-Protein FLS353 antibody, anti-Hepatocellular carcinoma-associated antigen 519 antibody, anti-targeting protein for Xklp2 antibody |
| ProteinTarget: | TPX2 (Targeting protein for Xklp2) |
| PackageSize: | 0.1 ml |
| GeneralRef: | 1. Heidebrecht H.J. et al. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. <i>Blood.</i> 90: 226-233(1997). 2. Garrett, S. et al. hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division. Curr. Biol. 12: 2055-2059 (2002). |