| CatalogCode: | NB400-117 |
| ProductName: | ABCG8 Antibody |
| Product Description: | Rabbit Polyclonal anti-ABCG8 |
| Clonality: | Polyclonal |
| Immunogen: | A synthetic peptide from the n-terminal region of human ABCG8 protein. |
| Specificity: | NB 400-117 is specific for human ABCG8. |
| CrossReactivity: | Human and mouse. Other species have not been tested. |
| Packaging: | 0.2 ml peptide affinity purified Rabbit antisera. |
| Uses: | A doublet is seen at ~67 and ~72 kDa in Western analysis. Longer exposure times are needed to visualize the wild type ABCG8. For mouse, 100 ug protein (B6/129AKRFVB liver homogenate) loaded with antibody diluted at 1:500 |
| Localization: | Integral membrane protein; multi-pass membrane protein |
| Background: | ATP-binding cassette (ABC) transporter genes are involved in the regulation of the amount of dietary cholesterol retained in the body. ABCG8, expressed at high levels in the liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption and promote biliary excretion of sterols. The mutated form of this transporter can lead to sterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessive disorder, characterized by hyperabsorption of sterols and the inability to excrete sterols into bile. |
| ProductRef: | 1. Mathur, S.N., Watt, K.R. and Field, F.J. (2007) Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid, J. Lipid Res., 48, 395-404. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | peptide affinity purified |
| Host_Name: | Rabbit |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-ATP binding cassette sub family G (WHITE) member 8 (sterolin 2) antibody; anti-ATP binding cassette sub family G member 8 antibody; anti-MGC142217 antibody; anti-Sterolin 2 antibody; anti-STSL antibody; anti-ATP binding cassette G8 antibody |
| ProteinTarget: | ABCG8 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Patel, S.B., et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8,respectively. Am. J. Hum. Genet., 69: 278-290, 2001. 2. Garcia, C.K., et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science, 292: 1394-1398, 2001. 3. Schmitz, G., et al. Role of ABCG1 and other ABCG family members in lipid metabolism. J. Lipid Res. 42: 1513-1519, 2001. |