| CatalogCode: | NB400-114 |
| ProductName: | Fatty Acid Synthase Antibody |
| Product Description: | Rabbit Polyclonal anti-Fatty Acid Synthase |
| Clonality: | Polyclonal |
| Immunogen: | An internal synthetic peptide, conjugated to KLH, made near the N-terminus of the mouse FAS protein sequence. |
| Specificity: | NB 400-114 is specific for FAS protein. |
| CrossReactivity: | NB 400-114 reacts with human, pig, chicken and mouse FAS. Other species have not been tested. |
| Packaging: | 0.1 ml Whole Rabbit antisera. |
| Uses: | NB 400-114 may be used for Western Blot where a band at ~272 kD should be seen on SDS-PAGE. May see 1 or 2 minor cross-reacting lower MW bands in liver tissue. |
| Localization: | Cytoplasmic |
| Control: | mouse liver lysate |
| Background: | FAS (Fatty Acid Synthase) is a central enzyme in de novo lipogenesis (triglyceride production). It is a target for SREBP and is upregulated by LXR activation. Fatty liver is often the result of FAS activation. It is also one of the accepted markers for insulin resistance and SREBP , LXR activation. |
| ProductRef: | 1. Gao, H., Bryzgalova, G., Hedman, E., Khan, A., Efendic, S., Gustafsson, J.-A., and Dahlman-Wright, K. (2006) Long-Term Administration of Estradiol Decreases Expression of Hepatic Lipogenic Genes and Improves Insulin Sensitivity in ob/ob Mice: A Possible Mechanism Is through Direct Regulation of Signal Transducer and Activator of Transcription 3, 20, 1287-1299. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Whole antisera |
| Host_Name: | Rabbit |
| ListPrice: | 285 |
| NovusRef: | 1. Dridi S. et al, "FAS inhibitor cerulenin reduces food intake and melanocortin receptor gene expression without modulating the other (an)orexigenic neuropeptides in chickens". Am J Physiol Regul Integr Comp Physiol. 2006 Jul;291(1):R138-47. Epub 2006 Feb 2. <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16455759&query_hl=1&itool=pubmed_docsum> 2. Gao, H., et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of Stat3. Mol. Endocrinol. 2006 3.Heemers, H.V., et al. Androgen Deprivation Increases p300 Expression in Prostate Cancer Cells. Cancer Res. 2007 67: 3422-3430. 4. Vavere, A. L., S. J. Kridel, et al. 1-11C-Acetate as a PET Radiopharmaceutical for Imaging Fatty Acid Synthase Expression in Prostate Cancer. J Nucl Med. 2008; 49: 327-334. |
| AppSummary: | IP, WB |
| SpeciesSummary: | Ch, Hu, Mu, Po |
| ALTnames: | anti-FAS antibody; anti-Acyl-carrier-protein] S-acetyltransferase antibody; anti-[Acyl-carrier-protein] S-malonyltransferase antibody; anti-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase antibody; anti-3-oxoacyl-[acyl-carrier-protein] reductase antibody; anti-3-oxoacyl-[acyl-carrier-protein] synthase antibody; anti-Enoyl-[acyl-carrier-protein] reductase antibody; anti-Oleoyl-[acyl-carrier-protein] hydrolase antibody |
| ProteinTarget: | Fatty Acid Synthase |
| PackageSize: | 0.1 ml |
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