| Catalog Code: | NB400-113 |
| Product Type: | Primary Antibody |
| Product Name: | SR-BI Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 949 |
| Host: | Rabbit |
| Product Description: | Rabbit Polyclonal anti-SR-BI |
| Cross Reactivity: | NB 400-113 reacts with mouse SR-BI. It can block human SR-BI/Cla-1 (tested in HepG2 cells). Other species have not been tested. |
| Species Summary: | Hu, Mu |
| Background: | High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI bi |
| Alternate Names: | anti-SCARB1 antibody, anti-SR-B1 antibody, anti-SR-BI antibody, anti-Scavenger Receptor-BI antibody, anti-Scavenger Receptor-B1 antibody |
| Immunogen: | Adenovirus encoding mSR-BI. |
| Specificity: | NB 400-113 is specific for SR-BI. |
| Packaging: | 0.1 ml Rabbit antisera. |
| Package Size: | 0.1 ml |
| Uses: | NB 400-113 may be used for immunoprecipitation and for blocking the binding of ligands to SR-BI. This antibody does not work well for western analysis. Immunoprecipitation: 1:100 Blocking: 1:500~1:1,000 Flow Cytometry: This lot has not been tested but p |
| Application Summary: | IP, BL |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| General References: | 1. Gu, X., et al. Scavenger Receptor Class B, Type I-mediated [3H] cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor. The Journal of Biological Chemistry. 275 (39): 29993-30001, 2000. |
| Product References: | 1. Wustner, D. et al. Different transport routes for high density lipoprotein and its association free sterol in polarized hepatic cells. Journal of Lipid Research. 45: 427-437, 2004. |
| Novus References: | 1. Francone, O.L., et al. Increased cholesterol deposition, expression of scavenger receptors and response to chemotactic factors in Abca1-deficient macrophages. Arterioscler. Thromb. Vasc. Biol. 25:1198-1205, 2005. |