| CatalogCode: | | NB300-862 |
| ProductName: | | CYLN2 Antibody |
| Product Description: | | Goat Polyclonal anti-CYLN2 |
| Clonality: | | Polyclonal |
| Immunogen: | | Synthetic peptide C-HQQDKAQKQEDKH, representing the C-Terminus of the human protein according to NP_003379; NP_115797. |
| CrossReactivity: | | Tested: Expected from sequence similarity: Human |
| Packaging: | | 0.1 mg Immunogen affinity purified Goat antisera. |
| Uses: | | This antibody can be used for ELISA and Western Blot. In Western Blot, preliminary experiments gave 3 bands at approx 150kDa, 125kDa and 100kDa in Human Brain lysates. Please note that currently we cannot find an explanation in the literature for the bands we observe given the predicted size of approx. 120kDda and 116kDa according to NP_003379 and NP_115797. Not tested in other applications.Peptide ELISA: 1:32,000WB: 0.1ug/ml*Optimal dilutions should be determined by the end user. |
| Background: | | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognize native protein in any application. The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Goat |
| Buffer: | | Tris-saline containing 0.02% Na azide [pH7.3] with 0.5% BSA |
| ListPrice: | | 195 |
| AppSummary: | | ELISA, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-CYLN2 antibody, anti-cytoplasmic linker 2 antibody, anti-WSCR4 antibody, anti-WBSCR4 antibody, anti-CLIP-115 antibody, anti-KIAA0291 antibody, anti-MGC11333 antibody, anti-Williams-Beuren syndrome chromosome region 4 antibody |
| ProteinTarget: | | CYLN2 |
| PackageSize: | | 0.1 mg |
| GeneralRef: | | Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. Genomics. 1996 Sep 1;36(2):328-36. PMID: 8812460 |
| NotesMain: | | **Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application. |
| Gene_Id: | | 7461 |
| Omim_ID: | | H00007461-M07 |
| more information: | | company product webpage |