| CatalogCode: | NB300-704 |
| ProductName: | PDE2A Antibody |
| Product Description: | Rabbit Polyclonal anti-PDE2A |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic peptide: ALSAVLPKVETV YTY, corresponding to N terminal amino acids 49-93 of Mouse PDE2A |
| CrossReactivity: | Cross-reacts with Human, Mouse, Dog and Rat. Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | WB: Detects a band of approximately 95-97 kDa in samples from rat brain. Optimal dilutions/concentrations should be determined by the end user. |
| Localization: | Cell Membrane |
| Control: | Rat brain. |
| Background: | Cyclic nucleotides are important intracellular second messengers which play an important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodiesterases. One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is PDE2. Two genes, PDE2A and PDE2B, have been identified and cloned and they both have an apparent molecular weight of 100 kDA. PDE2A has specificity for cAMP and its activity is modulated by the presence of cGMP. In contrast, PDE2B does not hydrolyze cGMP nor its activity is altered by the presence of cGMP. Western blot analyses of PDE2A reveals that it is present in a variety of tissues including neocortex, cerebellum, heart, kidney lungs, pulmonary artery and skeletal muscle. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Ca, Hu, Mu, Rt |
| ALTnames: | anti-PED2A4 antibody |
| ProteinTarget: | PDE2A antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Rascón A et al. Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. Proc Natl Acad Sci U S A 99:4714-9 (2002). Küthe A et al. Expression of different phosphodiesterase genes in human cavernous smooth muscle. J Urol 165:280-3 (2001). Sadhu K et al. Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells. J Histochem Cytochem 47:895-906 (1999). Farooqui SM et al. Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum. J Neurochem 57:1363-9 (1991). |
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