| Catalog Code: | NB300-635 |
| Product Type: | Primary Antibody |
| Product Name: | PDE4A Antibody |
| List Price: | 325 |
| Clonality: | Polyclonal |
| Gene ID: | 5141 |
| Host: | Rabbit |
| Isotype: | IgG |
| Product Description: | Rabbit Polyclonal anti-PDE4A [Ser] |
| Phosphorylated: | Ser |
| Cross Reactivity: | Cross-reacts with Human (weakly), Mouse, Rat and Rabbit.Not yet tested in other species. |
| Species Summary: | Mu, Rt, Rabbit |
| Background: | This antibody is ideal for studying phosphorylation dependent signal transduction research of PDE4 activation. |
| Immunogen: | Synthetic peptide corresponding to PKA phosphorylation site on PDE4A long form enzymes. The peptide was synthesized with phosphorylated serine. |
| Localization: | Cell Membrane |
| Specificity: | This antibody detects all known long-from variants of PDE4A, including PDE4A4, PDE4A5, PDE4A8, PDE4Ax when phosphorylated at the PKA phophorylation site. It will not cross-react with PDE4A phosphorylated at the ERK phosphorylation site. It does not cross- |
| Purity: | Immunogen affinity purified |
| Buffer: | Preservative: 0.02% Thimerosal / Merthiolate |
| Packaging: | 50 micrograms |
| Package Size: | 0.05 mg |
| Concentration: | 0.5 mg/ml |
| Uses: | IP: Use at an assay dependent dilution. WB: Use at a dilution of 1/2500. Detects bands at 66 kDa (PDE4A1), 109 kDa (PDE4A5), 106 kDa(PDE4A8), 102 kDa (PDE4Ax) and 76 kDa (testis specific PDE4A variant).Not tested in other applications.Optimal dilutions/co |
| Application Summary: | IP, WB |
| General References: | This product has been used in:Zhu B et al. Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Biochem Pharmacol 68:479-91 (2004). General / background references:Zhang HT et a |