| CatalogCode: | NB300-544 |
| ProductName: | Angiostatin Antibody |
| Product Description: | Rabbit Polyclonal anti-Angiostatin |
| Clonality: | Polyclonal |
| Immunogen: | Synthetic Peptide: V(1)YLSECKTGIGNGYRGTMS(19).Immunizing peptide corresponds to amino acid residues 1-19 from mouse angiostatin. This sequence is 95% and 84% conserved in rat and human angiostatin, respectively. |
| Specificity: | Detects recombinant human angiostatin. |
| CrossReactivity: | Cross-reacts with Human.Expected to cross-react with Rat and Mouse due to sequence homology.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Western Blot: use at a concentration of 2 ug/ml Not tested in other applications.Optimal dilutions / concentrations should be determined by the end user.By Western blot, this antibody detects a 50 kDa protein representing recombinant human angiostatin. |
| Background: | Angiostatin is a proteolytic fragment that comprises the first four kringle domains of the ~85 kDa plasminogen. Angiostatin reduces endothelial cell proliferation and acts as an potent inhibitor of angiogenesis and tumor growth. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS, 1 mg/ml BSA |
| ListPrice: | 295 |
| NovusRef: | 1. Agarwal, A., et al. N-Acetyl-Cysteine Promotes Angiostatin Production and Vascular Collapse in an Orthotopic Model of Breast Cancer. Am. J. Pathol. 164: 1683-1696, 2004. |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | Anti-Angiostatin antibody, anti- Microplasmin antibody |
| ProteinTarget: | Angiostatin Antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Sim BK et al. Angiostatin and endostatin: endogenous inhibitors of tumor growth. Cancer Metastasis Rev 19:181-90 (2000). Drixler TA et al. Angiogenesis and surgery: from mice to man. Eur J Surg 166:435-46 (2000). |