| CatalogCode: | NB300-533 |
| ProductName: | VAMP4 Antibody |
| Product Description: | Rabbit Polyclonal anti-VAMP4 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant full length protein (Rat). |
| CrossReactivity: | Cross-reacts with Human, Rat and Mouse.Not yet tested in other species. |
| Packaging: | 0.1 mg Immunogen affinity purified Rabbit antisera. |
| Uses: | Immunofluorescence: use at a concentration of 10 |
| Background: | The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP 25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer?s disease, VAMP levels of all isoforms appear to be significantly lowered. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | PBS, 1 mg/ml BSA, 0.05% sodium azide |
| ListPrice: | 295 |
| NovusRef: | 1. Williams D, Pessin JE. Mapping of R-SNARE function at distinct intracellular GLUT4 trafficking steps in adipocytes. J Cell Biol. 2008 January 28, 2008;180(2):375-87. |
| AppSummary: | IF |
| SpeciesSummary: | Hu, Mu, Rt |
| ProteinTarget: | VAMP 4 antibody |
| PackageSize: | 0.1 mg |
| GeneralRef: | General / background references:Kreykenbohm V et al. The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners. Eur J Cell Biol 81:273-80 (2002). |