| CatalogCode: | NB300-343 |
| ProductName: | alpha 2 Macroglobulin Antibody |
| Product Description: | Chicken Polyclonal anti-alpha 2 Macroglobulin |
| Clonality: | Polyclonal |
| Immunogen: | Full length protein (Human). |
| CrossReactivity: | Cross-reacts with Human, Mouse and Rat. Not yet tested in other species. |
| Packaging: | 0.05 mg Immunogen affinity purified Chicken antisera. |
| Uses: | WB: Predicted molecular weight: 163 kDa. Optimal dilutions/concentrations should be determined by the end user. |
| Background: | Alpha 2 macroglobulin is a serum protein which is mainly synthesised in the liver. It functions as a broad range irreversible proteinase inhibitor that forms a "trap" around most proteases. Alpha 2 macroglobulin is a tetrameric molecule, and with a molecular weight of 720 kDa, it so large a molecule that it tends to remain intravascular. Following conformational change the proteinase is deposited within a central cavity where it is still active but prevented from further contact with its substrate. Removal of the complex is mediated by the generation of recognition sites which react with receptors on a variety of cells including macrophages and liver cells. Alpha 2 macroglobulin is localized on the surface of peripheral blood lymphocytes. |
| Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgY |
| Host_Name: | Chicken |
| Buffer: | PBS |
| ListPrice: | 295 |
| AppSummary: | ELISA, WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-A2M antibody, anti-Alpha 2 M antibody, anti-Alpha 2M antibody, anti-CPAMD5 antibody, anti-DKFZp779B086 antibody, anti-FWP007 antibody, anti-S863 7 antibody |
| ProteinTarget: | alpha 2 Macroglobulin antibody |
| PackageSize: | 0.05 mg |
| GeneralRef: | General / background references:Dolmer K et al. Crystallisation and preliminary X-ray analysis of the receptor-binding domain of human and bovine alpha 2-macroglobulin. FEBS Lett 372:93-5 (1995). |